[HTML][HTML] Inhibition of NF-κB activation by arsenite through reaction with a critical cysteine in the activation loop of IκB kinase
Arsenite is a potent environmental toxin that causes various pathologies including cancers
and skin disorders. Arsenite is believed to exert its biological effects through reaction with
exposed sulfhydryl groups, especially pairs of adjacent thiols. Here, we describe the
mechanism by which arsenite affects the NF-κB signaling pathway. Activation of transcription
factor NF-κB depends on the integrity of the IκB kinase (IKK) complex. We found that arsenite
potently inhibits NF-κB and IKK activation by binding to Cys-179 in the activation loop of the …
and skin disorders. Arsenite is believed to exert its biological effects through reaction with
exposed sulfhydryl groups, especially pairs of adjacent thiols. Here, we describe the
mechanism by which arsenite affects the NF-κB signaling pathway. Activation of transcription
factor NF-κB depends on the integrity of the IκB kinase (IKK) complex. We found that arsenite
potently inhibits NF-κB and IKK activation by binding to Cys-179 in the activation loop of the …