A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B
AT Tan, S Koh, W Goh, HY Zhe, AJ Gehring, SG Lim… - Journal of …, 2010 - Elsevier
BACKGROUND AND AIMS: The pathogenesis of hepatic flares (HF) in patients chronically
infected with hepatitis B virus (HBV) is controversial. Therefore, we studied the kinetics of
innate and adaptive immune activation during HF in chronic hepatitis B. METHODS: Soluble
(IFN-α, IL-1β, TNF-α, IL-6, IL-8, IL-10, CCL-2, CCL-3, CXCL-9, CXCL-10) and cellular (HBV-
specific T cells, NK, Treg) immunological parameters were measured longitudinally
(10month–4week intervals) in patients (n= 5) who developed HF after therapy withdrawal …
infected with hepatitis B virus (HBV) is controversial. Therefore, we studied the kinetics of
innate and adaptive immune activation during HF in chronic hepatitis B. METHODS: Soluble
(IFN-α, IL-1β, TNF-α, IL-6, IL-8, IL-10, CCL-2, CCL-3, CXCL-9, CXCL-10) and cellular (HBV-
specific T cells, NK, Treg) immunological parameters were measured longitudinally
(10month–4week intervals) in patients (n= 5) who developed HF after therapy withdrawal …