Early onset of reproductive function in normal female mice treated with leptin
FF Chehab, K Mounzih, R Lu, ME Lim - Science, 1997 - science.org
FF Chehab, K Mounzih, R Lu, ME Lim
Science, 1997•science.orgNumerous studies have revealed an association between nutritional status, adiposity, and
reproductive maturity. The role of leptin, a hormone secreted from adipose tissue, in the
onset of reproductive function was investigated. Normal prepubertal female mice injected
with leptin grew at a slower rate than controls as a result of the hormone's thinning effects,
but they reproduced up to 9 days earlier than controls and showed earlier maturation of the
reproductive tract. These results suggest that leptin acts as a signal triggering puberty, thus …
reproductive maturity. The role of leptin, a hormone secreted from adipose tissue, in the
onset of reproductive function was investigated. Normal prepubertal female mice injected
with leptin grew at a slower rate than controls as a result of the hormone's thinning effects,
but they reproduced up to 9 days earlier than controls and showed earlier maturation of the
reproductive tract. These results suggest that leptin acts as a signal triggering puberty, thus …
Numerous studies have revealed an association between nutritional status, adiposity, and reproductive maturity. The role of leptin, a hormone secreted from adipose tissue, in the onset of reproductive function was investigated. Normal prepubertal female mice injected with leptin grew at a slower rate than controls as a result of the hormone's thinning effects, but they reproduced up to 9 days earlier than controls and showed earlier maturation of the reproductive tract. These results suggest that leptin acts as a signal triggering puberty, thus supporting the hypothesis that fat accumulation enhances maturation of the reproductive tract.
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