Cell cycle regulation and biochemical responses upon nutrients and growth factors are the
major regulatory mechanisms for cell sizing in mammals. Recently, we identified that the
death effector domain-containing DEDD impedes mitotic progression by inhibiting Cdk1
(cyclin-dependent kinase 1) and thus maintains an increase of cell size during the mitotic
phase. Here we found that DEDD also associates with S6 kinase 1 (S6K1), downstream of
phosphatidylinositol 3-kinase, and supports its activity by preventing inhibitory …