Current concepts in the pathogenesis of age-related macular degeneration

MA Zarbin - Archives of ophthalmology, 2004 - jamanetwork.com
Objective To review and synthesize information concerning the pathogenesis ofage-related
macular degeneration (AMD). Methods Review of the English-language literature. Results
Five concepts relevant to the cell biology of AMD are as follows:(1) AMD involves aging
changes plus additional pathological changes (ie, AMD isnot just an aging change);(2) in
aging and AMD, oxidative stress causes retinalpigment epithelial (RPE) and, possibly,
choriocapillaris injury;(3) in AMD (and perhaps in aging), RPE and, possibly, choriocapillaris …