The role of apoptosis in age-related macular degeneration

JL Dunaief, T Dentchev, GS Ying… - Archives of …, 2002 - jamanetwork.com
Objective To investigate apoptosis in human age-related macular degeneration (AMD).
Methods Postmortem retinas with AMD and normal retinas were studied by terminal
deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) to identify dying cells, and by
immunocytochemistry with cell-specific antibodies to identify rods and cones. Sections were
also labeled for Fas, a cell surface receptor that triggers apoptosis in other cell types. The
maculas with AMD had geographic atrophy (GA) or exudative AMD. Results Maculas with …