[HTML][HTML] Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells
H Tronchere, J Laporte, C Pendaries… - Journal of Biological …, 2004 - ASBMB
MTM1, the gene encoding myotubularin (MTM1), is mutated in the X-linked myotubular
myopathy (XLMTM), a severe genetic muscular disorder. MTM1 is a phosphoinositide
phosphatase hydrolyzing phosphatidylinositol 3-phosphate (PtdIns (3) P) in yeast and in
vitro. Because this lipid is implicated in the regulation of vesicular trafficking, we used
established cell lines from XLMTM patients to evaluate whether the lack of endogenous
MTM1 expression could affect PtdIns (3) P labeling patterns. Our results showed that the …
myopathy (XLMTM), a severe genetic muscular disorder. MTM1 is a phosphoinositide
phosphatase hydrolyzing phosphatidylinositol 3-phosphate (PtdIns (3) P) in yeast and in
vitro. Because this lipid is implicated in the regulation of vesicular trafficking, we used
established cell lines from XLMTM patients to evaluate whether the lack of endogenous
MTM1 expression could affect PtdIns (3) P labeling patterns. Our results showed that the …