[HTML][HTML] Oncogenic Ha-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation
TS Finco, JK Westwick, JL Norris, AA Beg… - Journal of Biological …, 1997 - ASBMB
Ras proteins function in stimulating cell proliferation and differentiation through the
activation of Raf-dependent and Raf-independent signal transduction pathways and the
subsequent activation of specific transcription factors. The transcription factor NF-κB has
been widely studied as a regulator of genes involved in immune and inflammatory
responses. A variety of stimuli activate NF-κB through the induced phosphorylation and
degradation of the inhibitor IκB followed by nuclear translocation of NF-κB. We show here …
activation of Raf-dependent and Raf-independent signal transduction pathways and the
subsequent activation of specific transcription factors. The transcription factor NF-κB has
been widely studied as a regulator of genes involved in immune and inflammatory
responses. A variety of stimuli activate NF-κB through the induced phosphorylation and
degradation of the inhibitor IκB followed by nuclear translocation of NF-κB. We show here …