[HTML][HTML] Akt is a downstream target of NF-κB
The ubiquitously expressed transcription factor NF-κB and the serine-threonine kinase Akt
both are involved in the promotion of cell survival. Although initially believed to operate as
components of distinct signaling pathways, several studies have demonstrated that the NF-
κB and Akt signaling pathways can converge. Indeed, IκB kinase, the kinase involved in NF-
κB activation, is a substrate of Akt, and activation of Akt therefore stimulates NF-κB activity.
Although these results place Akt upstream of NF-κB activation in the sequence of signaling …
both are involved in the promotion of cell survival. Although initially believed to operate as
components of distinct signaling pathways, several studies have demonstrated that the NF-
κB and Akt signaling pathways can converge. Indeed, IκB kinase, the kinase involved in NF-
κB activation, is a substrate of Akt, and activation of Akt therefore stimulates NF-κB activity.
Although these results place Akt upstream of NF-κB activation in the sequence of signaling …