Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas
JI Pritchard, JM Olson - Cancer genetics and cytogenetics, 2008 - Elsevier
The Sonic hedgehog (Shh) pathway is aberrantly activated in a subset of the most common
malignant pediatric brain tumor, medulloblastoma (MB). Shh pathway activity is measured
by expression of the target genes in the GLI family, MYCN and PTCH1, a tumor suppressor
and negative regulator of the pathway. Promoter methylation of tumor suppressors is
implicated in tumor formation by gene silencing. In this study, we examined whether the
proximal promoter of the PTCH1 gene (variant exon 1B) is methylated in some cases of MB …
malignant pediatric brain tumor, medulloblastoma (MB). Shh pathway activity is measured
by expression of the target genes in the GLI family, MYCN and PTCH1, a tumor suppressor
and negative regulator of the pathway. Promoter methylation of tumor suppressors is
implicated in tumor formation by gene silencing. In this study, we examined whether the
proximal promoter of the PTCH1 gene (variant exon 1B) is methylated in some cases of MB …