Antimony trioxide-induced apoptosis is dependent on SEK1/JNK signaling
KK Mann, K Davison, M Colombo, AL Colosimo, Z Diaz… - Toxicology letters, 2006 - Elsevier
Very little is known concerning the toxicity of antimony, despite its commercial use as a flame
retardant and medical use as a treatment for parasitic infections. Our previous studies show
that antimony trioxide (Sb2O3) induces growth inhibition in patient-derived acute
promyelocytic leukemia (APL) cell lines, a disease in which a related metal, arsenic trioxide
(As2O3), is used clinically. However, signaling pathways initiated by Sb2O3 treatment
remain undefined. Here, we show that Sb2O3 treatment of APL cells is associated with …
retardant and medical use as a treatment for parasitic infections. Our previous studies show
that antimony trioxide (Sb2O3) induces growth inhibition in patient-derived acute
promyelocytic leukemia (APL) cell lines, a disease in which a related metal, arsenic trioxide
(As2O3), is used clinically. However, signaling pathways initiated by Sb2O3 treatment
remain undefined. Here, we show that Sb2O3 treatment of APL cells is associated with …