C/EBPα induces PU. 1 and interacts with AP-1 and NF-κB to regulate myeloid development
AD Friedman - Blood Cells, Molecules, and Diseases, 2007 - Elsevier
C/EBPα and PU. 1 are key regulators of early myeloid development. Mice lacking C/EBPα or
PU. 1 have reduced granulocytes and monocytes. Consistent with a model in which
induction of PU. 1 by C/EBPα contributes to monocyte lineage specification, mice with
reduced PU. 1 have diminished monocytes but retain granulocytes, C/EBPα directly
activates PU. 1 gene transcription, and exogenous C/EBPα increases monocytic lineage
commitment from bipotential myeloid progenitors. In addition to C/EBPα, AP-1 proteins also …
PU. 1 have reduced granulocytes and monocytes. Consistent with a model in which
induction of PU. 1 by C/EBPα contributes to monocyte lineage specification, mice with
reduced PU. 1 have diminished monocytes but retain granulocytes, C/EBPα directly
activates PU. 1 gene transcription, and exogenous C/EBPα increases monocytic lineage
commitment from bipotential myeloid progenitors. In addition to C/EBPα, AP-1 proteins also …
