Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid
G Duester, FA Mic, A Molotkov - Chemico-biological interactions, 2003 - Elsevier
The ability of vitamin A (retinol) to control growth and development depends upon tissue-
specific metabolism of retinol to retinoic acid (RA). RA then functions as a ligand for retinoid
receptor signaling. Mouse genetic studies support a role for cytosolic alcohol
dehydrogenases (ADH) in the first step (oxidation of retinol to retinaldehyde) and a role for
cytosolic retinaldehyde dehydrogenases (RALDH) in the second step (oxidation of
retinaldehyde to RA). Mice lacking ADH3 have reduced survival and a growth defect that …
specific metabolism of retinol to retinoic acid (RA). RA then functions as a ligand for retinoid
receptor signaling. Mouse genetic studies support a role for cytosolic alcohol
dehydrogenases (ADH) in the first step (oxidation of retinol to retinaldehyde) and a role for
cytosolic retinaldehyde dehydrogenases (RALDH) in the second step (oxidation of
retinaldehyde to RA). Mice lacking ADH3 have reduced survival and a growth defect that …