Metastasis suppressors alter the signal transduction of cancer cells
PS Steeg - Nature Reviews Cancer, 2003 - nature.com
PS Steeg
Nature Reviews Cancer, 2003•nature.comTumour metastasis is a significant contributor to death in cancer patients. Eight metastasis-
suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without
affecting its tumorigenicity have been identified. These affect important signal-transduction
pathways, including mitogen-activated protein kinases, RHO, RAC and G-protein-coupled
and tyrosine-kinase receptors. So how might we use this knowledge to improve the
treatment of patients with cancer?
suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without
affecting its tumorigenicity have been identified. These affect important signal-transduction
pathways, including mitogen-activated protein kinases, RHO, RAC and G-protein-coupled
and tyrosine-kinase receptors. So how might we use this knowledge to improve the
treatment of patients with cancer?
Abstract
Tumour metastasis is a significant contributor to death in cancer patients. Eight metastasis-suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without affecting its tumorigenicity have been identified. These affect important signal-transduction pathways, including mitogen-activated protein kinases, RHO, RAC and G-protein-coupled and tyrosine-kinase receptors. So how might we use this knowledge to improve the treatment of patients with cancer?
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