Tumor metastasis: mechanistic insights and clinical challenges
PS Steeg - Nature medicine, 2006 - nature.com
PS Steeg
Nature medicine, 2006•nature.comMetastatic disease is the primary cause of death for most cancer patients. Complex and
redundant pathways involving the tumor cell and the microenvironment mediate tumor
invasion at the primary site, survival and arrest in the bloodstream, and progressive
outgrowth at a distant site. Understanding these pathways and their dynamic interactions will
help identify promising molecular targets for cancer therapy and key obstacles to their
clinical development.
redundant pathways involving the tumor cell and the microenvironment mediate tumor
invasion at the primary site, survival and arrest in the bloodstream, and progressive
outgrowth at a distant site. Understanding these pathways and their dynamic interactions will
help identify promising molecular targets for cancer therapy and key obstacles to their
clinical development.
Metastatic disease is the primary cause of death for most cancer patients. Complex and redundant pathways involving the tumor cell and the microenvironment mediate tumor invasion at the primary site, survival and arrest in the bloodstream, and progressive outgrowth at a distant site. Understanding these pathways and their dynamic interactions will help identify promising molecular targets for cancer therapy and key obstacles to their clinical development.
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