[HTML][HTML] Mesodermal deletion of transforming growth factor-β receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-β and Sonic hedgehog …
M Li, C Li, Y Liu, Y Xing, L Hu, Z Borok… - Journal of biological …, 2008 - ASBMB
In vertebrates, Sonic hedgehog (Shh) and transforming growth factor-β (TGF-β) signaling
pathways occur in an overlapping manner in many morphogenetic processes. In vitro data
indicate that the two pathways may interact. Whether such interactions occur during
embryonic development remains unknown. Using embryonic lung morphogenesis as a
model, we generated transgenic mice in which exon 2 of the TβRII gene, which encodes the
type II TGF-β receptor, was deleted via a mesodermal-specific Cre. Mesodermal-specific …
pathways occur in an overlapping manner in many morphogenetic processes. In vitro data
indicate that the two pathways may interact. Whether such interactions occur during
embryonic development remains unknown. Using embryonic lung morphogenesis as a
model, we generated transgenic mice in which exon 2 of the TβRII gene, which encodes the
type II TGF-β receptor, was deleted via a mesodermal-specific Cre. Mesodermal-specific …