The increasing complexity of the cancer stem cell paradigm
The investigation and study of cancer stem cells (CSCs) have received enormous attention
over the past 5 to 10 years but remain topics of considerable controversy. Opinions about
the validity of the CSC hypothesis, the biological properties of CSCs, and the relevance of
CSCs to cancer therapy differ widely. In the following commentary, we discuss the nature of
the debate, the parameters by which CSCs can or cannot be defined, and the identification
of new potential therapeutic targets elucidated by considering cancer as a problem in stem …
over the past 5 to 10 years but remain topics of considerable controversy. Opinions about
the validity of the CSC hypothesis, the biological properties of CSCs, and the relevance of
CSCs to cancer therapy differ widely. In the following commentary, we discuss the nature of
the debate, the parameters by which CSCs can or cannot be defined, and the identification
of new potential therapeutic targets elucidated by considering cancer as a problem in stem …
The investigation and study of cancer stem cells (CSCs) have received enormous attention over the past 5 to 10 years but remain topics of considerable controversy. Opinions about the validity of the CSC hypothesis, the biological properties of CSCs, and the relevance of CSCs to cancer therapy differ widely. In the following commentary, we discuss the nature of the debate, the parameters by which CSCs can or cannot be defined, and the identification of new potential therapeutic targets elucidated by considering cancer as a problem in stem cell biology.
AAAS