Resolution of endothelial activation and down-regulation of Tie2 receptor in psoriatic skin after infliximab therapy

T Markham, R Mullan, L Golden-Mason… - Journal of the American …, 2006 - Elsevier
BACKGROUND: Psoriasis is a common dermatosis characterized by erythematous skin
plaques and associated arthritis. Microvessels of the papillary dermis in psoriatic lesions are
elongated, tortuous, and dilated, which contributes significantly to the proinflammatory
response. Angiopoietin (Ang) 1 and 2 and their receptor, Tie2, are a family of growth factors
recognized in inflammatory lesions to be critical for new blood vessel growth and
maintenance, with recent studies suggesting tumor necrosis factor (TNF)-α-induced …