sel-10, a negative regulator of lin-12 activity inCaenorhabditis elegans, encodes a member of the CDC4 family of proteins
EJA Hubbard, G Wu, J Kitajewski… - Genes & …, 1997 - genesdev.cshlp.org
Genes & development, 1997•genesdev.cshlp.org
Mutations that influence lin-12 activity in Caenorhabditis elegans may identify conserved
factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence
indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C.
elegans. Sequence analysis shows that SEL-10 is a member of the CDC4 family of proteins
and has a potential human ortholog. Coimmunoprecipitation data indicate that C. elegans
SEL-10 complexes with LIN-12 and with murine Notch4. We propose that SEL-10 promotes …
factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence
indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C.
elegans. Sequence analysis shows that SEL-10 is a member of the CDC4 family of proteins
and has a potential human ortholog. Coimmunoprecipitation data indicate that C. elegans
SEL-10 complexes with LIN-12 and with murine Notch4. We propose that SEL-10 promotes …
Mutations that influence lin-12 activity inCaenorhabditis elegans may identify conserved factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C. elegans. Sequence analysis shows that SEL-10 is a member of the CDC4 family of proteins and has a potential human ortholog. Coimmunoprecipitation data indicate that C. elegansSEL-10 complexes with LIN-12 and with murine Notch4. We propose that SEL-10 promotes the ubiquitin-mediated turnover of LIN-12/Notch proteins, and discuss potential roles for the regulation of lin-12/Notch activity bysel-10 in cell fate decisions and tumorigenesis.
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