[HTML][HTML] A phosphorylation cascade controls the degradation of active SREBP1
MT Bengoechea-Alonso, J Ericsson - Journal of Biological Chemistry, 2009 - ASBMB
Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that
regulates cholesterol and lipid metabolism. The active forms of these transcription factors
are targeted by a number of post-translational modifications, including phosphorylation.
Phosphorylation of Thr-426 and Ser-430 in SREBP1a creates a docking site for the ubiquitin
ligase Fbw7, resulting in the degradation of the transcription factor. Here, we identify a novel
phosphorylation site in SREBP1a, Ser-434, which regulates the Fbw7-dependent …
regulates cholesterol and lipid metabolism. The active forms of these transcription factors
are targeted by a number of post-translational modifications, including phosphorylation.
Phosphorylation of Thr-426 and Ser-430 in SREBP1a creates a docking site for the ubiquitin
ligase Fbw7, resulting in the degradation of the transcription factor. Here, we identify a novel
phosphorylation site in SREBP1a, Ser-434, which regulates the Fbw7-dependent …