Chemokines coordinate many aspects of leukocyte migration. As chemoattractants they play
an important role in the innate and acquired immune response. There is good experimental
evidence that N-terminal truncation by secreted or cell surface proteases is a way of
modulating chemokine action. The localization of CD26/dipeptidyl peptidase IV on cell
surfaces and in biological fluids, its primary specificity, and the type of naturally occurring
truncated chemokines are consistent with such a function. We determined the steady-state …