[HTML][HTML] Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2-and BMP6 …
M Nili, U Shinde, P Rotwein - Journal of biological chemistry, 2010 - ASBMB
Inactivating mutations in hemojuvelin/repulsive guidance molecule c (HJV/RGMc) cause
juvenile hemochromatosis (JH), a rapidly progressive iron overload disorder in which
expression of hepcidin, a key liver-derived iron-regulatory hormone, is severely diminished.
Several growth factors in the bone morphogenetic protein (BMP) family, including BMP2 and
BMP6, can stimulate production of hepcidin, a biological effect that may be modified by
RGMc. Here we demonstrate that soluble RGMc proteins are potent BMP inhibitors. We find …
juvenile hemochromatosis (JH), a rapidly progressive iron overload disorder in which
expression of hepcidin, a key liver-derived iron-regulatory hormone, is severely diminished.
Several growth factors in the bone morphogenetic protein (BMP) family, including BMP2 and
BMP6, can stimulate production of hepcidin, a biological effect that may be modified by
RGMc. Here we demonstrate that soluble RGMc proteins are potent BMP inhibitors. We find …