Regression of fetal cerebral abnormalities by primary cytomegalovirus infection following hyperimmunoglobulin therapy
G Nigro, RL Torre, H Pentimalli… - … in Affiliation With the …, 2008 - Wiley Online Library
G Nigro, RL Torre, H Pentimalli, P Taverna, M Lituania, BM de Tejada, SP Adler
Prenatal Diagnosis: Published in Affiliation With the …, 2008•Wiley Online LibraryObjective To assess the effects of maternal and intra‐amniotic hyperimmunoglobulin (HIG)
infusions among cytomegalovirus (CMV) infected fetuses with ultrasound abnormalities
following a primary CMV infection. Patients and Methods The subjects were fetuses with
CMV‐associated cerebral and other ultrasound abnormalities. Three mothers were treated
with HIG infusions during pregnancy and two were untreated. Fetal ventricle size, organ
echodensity and placental thickness were measured by ultrasound before and after HIG …
infusions among cytomegalovirus (CMV) infected fetuses with ultrasound abnormalities
following a primary CMV infection. Patients and Methods The subjects were fetuses with
CMV‐associated cerebral and other ultrasound abnormalities. Three mothers were treated
with HIG infusions during pregnancy and two were untreated. Fetal ventricle size, organ
echodensity and placental thickness were measured by ultrasound before and after HIG …
Objective
To assess the effects of maternal and intra‐amniotic hyperimmunoglobulin (HIG) infusions among cytomegalovirus (CMV) infected fetuses with ultrasound abnormalities following a primary CMV infection.
Patients and Methods
The subjects were fetuses with CMV‐associated cerebral and other ultrasound abnormalities. Three mothers were treated with HIG infusions during pregnancy and two were untreated. Fetal ventricle size, organ echodensity and placental thickness were measured by ultrasound before and after HIG infusions. The children were evaluated between 3 and 7 years of age.
Results
The ventriculomegaly of all three fetuses of HIG‐treated mothers regressed and the ascites, hepatic echodensities, periventricular echodensities, and intestinal echodensities disappeared. Their sensorial, mental and motor development was normal at 4, 4.7, and 7 years of age. In contrast, both infants born of untreated mothers had signs and symptoms of severe CMV cerebropathy.
Conclusion
The outcomes of the infants born to HIG‐treated mothers support the efficacy of HIG as a treatment for CMV‐infected fetuses with ultrasound cerebral abnormalities. Copyright © 2008 John Wiley & Sons, Ltd.
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