[HTML][HTML] The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-κB
Y Higuchi, K Otsu, K Nishida, S Hirotani… - Journal of Biological …, 2003 - ASBMB
The small guanine nucleotide-binding protein Rac1 has emerged as an important molecule
involved in cardiac myocyte hypertrophy. Recently, we reported on apoptosis signal-
regulating kinase (ASK) 1 and a transcriptional factor, nuclear factor-κB (NF-κB), as novel
signaling intermediates in cardiac myocyte hypertrophy. The aim of the study presented here
was to clarify the role of Rac1 in the ASK1-NF-κB signaling pathway. Infection of isolated
neonatal cardiac myocytes with an adenovirus expressing a constitutively active form of …
involved in cardiac myocyte hypertrophy. Recently, we reported on apoptosis signal-
regulating kinase (ASK) 1 and a transcriptional factor, nuclear factor-κB (NF-κB), as novel
signaling intermediates in cardiac myocyte hypertrophy. The aim of the study presented here
was to clarify the role of Rac1 in the ASK1-NF-κB signaling pathway. Infection of isolated
neonatal cardiac myocytes with an adenovirus expressing a constitutively active form of …