[HTML][HTML] Targeting LFA-1 synergizes with CD40/CD40L blockade for suppression of both CD4-dependent and CD8-dependent rejection
Y Wang, D Gao, KE Lunsford, WL Frankel… - American Journal of …, 2003 - Elsevier
Allogeneic hepatocytes elicit CD4-dependent and (CD4-independent) CD8+ T-cell-initiated
graft rejection. The (CD4-independent) CD8+ T-cell pathway is resistant to
immunosuppressive strategies that readily and indefinitely suppress CD4+ T-cell-dependent
rejection responses. Consequently, successful immunoregulation of hepatocyte-initiated
immune responses requires a strategy which regulates both CD4-dependent and CD8-
dependent rejection responses. Interference with CD40/CD40 ligand (CD40L) costimulation …
graft rejection. The (CD4-independent) CD8+ T-cell pathway is resistant to
immunosuppressive strategies that readily and indefinitely suppress CD4+ T-cell-dependent
rejection responses. Consequently, successful immunoregulation of hepatocyte-initiated
immune responses requires a strategy which regulates both CD4-dependent and CD8-
dependent rejection responses. Interference with CD40/CD40 ligand (CD40L) costimulation …