[HTML][HTML] The influence of superoxide dismutase and glutathione peroxidase deficiencies on noise-induced hearing loss in mice
SL McFadden, KK Ohlemiller, D Ding, M Shero… - Noise and …, 2001 - journals.lww.com
One consequence of noise exposure is increased production of reactive oxygen species
(ROS), such as superoxide, hydrogen peroxide, and hydroxyl radicals, in the cochlea. ROS
can cause oxidative damage to diverse cellular components, including membranes,
proteins, and DNA, if they are not" neutralised" by antioxidant defences. Two important
enzymes of the cochlear antioxidant defense system are cytosolic copper/zinc superoxide
dismutase (SOD1) and selenium-dependent glutathione peroxidase (GPx1). These …
(ROS), such as superoxide, hydrogen peroxide, and hydroxyl radicals, in the cochlea. ROS
can cause oxidative damage to diverse cellular components, including membranes,
proteins, and DNA, if they are not" neutralised" by antioxidant defences. Two important
enzymes of the cochlear antioxidant defense system are cytosolic copper/zinc superoxide
dismutase (SOD1) and selenium-dependent glutathione peroxidase (GPx1). These …