The role of HOX genes in malignant myeloid disease
EA Eklund - Current opinion in hematology, 2007 - journals.lww.com
EA Eklund
Current opinion in hematology, 2007•journals.lww.comThese findings suggest that a key characteristic of poor prognosis acute myeloid leukemia is
increased, differentiation-stage inappropriate expression of the Abd HoxA proteins and their
DNA-binding partners. Such results suggest that dysregulation of the 'Hox code'is important
in the pathogenesis of myeloid malignancy.
increased, differentiation-stage inappropriate expression of the Abd HoxA proteins and their
DNA-binding partners. Such results suggest that dysregulation of the 'Hox code'is important
in the pathogenesis of myeloid malignancy.
Summary
These findings suggest that a key characteristic of poor prognosis acute myeloid leukemia is increased, differentiation-stage inappropriate expression of the Abd HoxA proteins and their DNA-binding partners. Such results suggest that dysregulation of the ‘Hox code’is important in the pathogenesis of myeloid malignancy.
Lippincott Williams & Wilkins