[HTML][HTML] Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines
S Sakajiri, T Kumagai, N Kawamata, T Saitoh… - Experimental …, 2005 - Elsevier
Methylation of tumor suppressor genes is frequently observed in human cancers. These
genes are silenced by histone deacetylase (HDAC) recruited by methylated DNA in their
promoter regions. HDAC removes acetyl groups from histones and prevents the basic
transcriptional machinary access to the target gene, leading to transcriptional repression.
HDAC inhibitors (HDACIs) can restore the expression of the tumor suppressor and/or cell
cycle regulatory genes in cancer cells and block the cellular proliferation of these cells. In …
genes are silenced by histone deacetylase (HDAC) recruited by methylated DNA in their
promoter regions. HDAC removes acetyl groups from histones and prevents the basic
transcriptional machinary access to the target gene, leading to transcriptional repression.
HDAC inhibitors (HDACIs) can restore the expression of the tumor suppressor and/or cell
cycle regulatory genes in cancer cells and block the cellular proliferation of these cells. In …