[HTML][HTML] HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling
VD Kekatpure, AJ Dannenberg… - Journal of Biological …, 2009 - ASBMB
The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-
helix family of transcription factors, binds with high affinity to polycyclic aromatic
hydrocarbons (PAH) and the environmental toxin 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin
(dioxin). Most of the biochemical, biological, and toxicological responses caused by
exposure to PAHs and polychlorinated dioxins are mediated, at least in part, by the AhR.
The AhR is a client protein of Hsp90, a molecular chaperone that can be reversibly …
helix family of transcription factors, binds with high affinity to polycyclic aromatic
hydrocarbons (PAH) and the environmental toxin 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin
(dioxin). Most of the biochemical, biological, and toxicological responses caused by
exposure to PAHs and polychlorinated dioxins are mediated, at least in part, by the AhR.
The AhR is a client protein of Hsp90, a molecular chaperone that can be reversibly …