[HTML][HTML] Modes of p53 regulation

JP Kruse, W Gu - Cell, 2009 - cell.com
JP Kruse, W Gu
Cell, 2009cell.com
The traditional view of p53 activation includes three steps—p53 stabilization, DNA binding,
and transcriptional activation. However, recent studies indicate that each step of p53
activation is more complex than originally anticipated. Moreover, both genetic studies in
mice and in vitro studies with purified components suggest that the classical model may not
be sufficient to explain all aspects of p53 activation in vivo. To reconcile these differences,
we propose that antirepression, the release of p53 from repression by factors such as Mdm2 …
The traditional view of p53 activation includes three steps—p53 stabilization, DNA binding, and transcriptional activation. However, recent studies indicate that each step of p53 activation is more complex than originally anticipated. Moreover, both genetic studies in mice and in vitro studies with purified components suggest that the classical model may not be sufficient to explain all aspects of p53 activation in vivo. To reconcile these differences, we propose that antirepression, the release of p53 from repression by factors such as Mdm2 and MdmX, is a key step in the physiological activation of p53.
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