Chromatin loops in gene regulation

S Kadauke, GA Blobel - Biochimica et Biophysica Acta (BBA)-Gene …, 2009 - Elsevier
S Kadauke, GA Blobel
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 2009Elsevier
The control of gene expression involves regulatory elements that can be very far from the
genes they control. Several recent technological advances have allowed the direct detection
of chromatin loops that juxtapose distant genomic sites in the nucleus. Here we review
recent studies from various model organisms that have provided new insights into the
functions of chromatin loops and the mechanisms that form them. We discuss the
widespread impact of chromatin loops on gene activation, repression, genomic imprinting …
The control of gene expression involves regulatory elements that can be very far from the genes they control. Several recent technological advances have allowed the direct detection of chromatin loops that juxtapose distant genomic sites in the nucleus. Here we review recent studies from various model organisms that have provided new insights into the functions of chromatin loops and the mechanisms that form them. We discuss the widespread impact of chromatin loops on gene activation, repression, genomic imprinting and the function of enhancers and insulators.
Elsevier