[HTML][HTML] Major erythrocyte membrane protein genes in EKLF-deficient mice
DG Nilson, DE Sabatino, DM Bodine… - Experimental …, 2006 - Elsevier
OBJECTIVES: Mice deficient in the transcription factor erythroid Krüppel-like factor, KLF1
(EKLF) die∼ 14.5 days postcoitum of anemia, attributed to decreased expression of the β-
globin gene. The objectives of this study were to rescue EKLF-deficient embryos with mice
expressing γ-globin from β-spectrin or ankyrin promoters and to characterize expression of
the major erythrocyte membrane genes in EKLF-deficient cells. METHODS: Transgenic β-
spectrin/γ-globin or ankyrin/γ-globin mice were bred onto EKLF-deficient and wild-type …
(EKLF) die∼ 14.5 days postcoitum of anemia, attributed to decreased expression of the β-
globin gene. The objectives of this study were to rescue EKLF-deficient embryos with mice
expressing γ-globin from β-spectrin or ankyrin promoters and to characterize expression of
the major erythrocyte membrane genes in EKLF-deficient cells. METHODS: Transgenic β-
spectrin/γ-globin or ankyrin/γ-globin mice were bred onto EKLF-deficient and wild-type …