[HTML][HTML] The SCL 3′ enhancer responds to Hedgehog signaling during hemangioblast specification
E Hochman, S Kinston, A Harmelin, B Göttgens… - Experimental …, 2006 - Elsevier
OBJECTIVE: The Hedgehog family of intercellular proteins has a crucial role in embryonic
development. Recent experimental data suggests that the Hedgehog pathway may play a
role in early hematopoiesis and angiogenesis. Stem cell leukemia (SCL), a basic helix-loop-
helix (bHLH) transcription factor, is essential for the specification and function of the
hemangioblast. SCL expression in early hematopoietic precursors and endothelium is
directed by a 3′ enhancer. We hypothesized that the SCL 3′ enhancer is regulated by …
development. Recent experimental data suggests that the Hedgehog pathway may play a
role in early hematopoiesis and angiogenesis. Stem cell leukemia (SCL), a basic helix-loop-
helix (bHLH) transcription factor, is essential for the specification and function of the
hemangioblast. SCL expression in early hematopoietic precursors and endothelium is
directed by a 3′ enhancer. We hypothesized that the SCL 3′ enhancer is regulated by …