[HTML][HTML] Oxidation of either methionine 351 or methionine 358 in α1-antitrypsin causes loss of anti-neutrophil elastase activity
C Taggart, D Cervantes-Laurean, G Kim… - Journal of Biological …, 2000 - ASBMB
Hydrogen peroxide is a component of cigarette smoke known to be essential for inactivation
of α 1-antitrypsin, the primary inhibitor of neutrophil elastase. To establish the molecular
basis of the inactivation of α 1-antitrypsin, we determined the sites oxidized by hydrogen
peroxide. Two of the nine methionines were particularly susceptible to oxidation. One was
methionine 358, whose oxidation was known to cause loss of anti-elastase activity. The
other, methionine 351, was as susceptible to oxidation as methionine 358. Its oxidation also …
of α 1-antitrypsin, the primary inhibitor of neutrophil elastase. To establish the molecular
basis of the inactivation of α 1-antitrypsin, we determined the sites oxidized by hydrogen
peroxide. Two of the nine methionines were particularly susceptible to oxidation. One was
methionine 358, whose oxidation was known to cause loss of anti-elastase activity. The
other, methionine 351, was as susceptible to oxidation as methionine 358. Its oxidation also …