[HTML][HTML] Interleukin-8-induced priming of neutrophil oxidative burst requires sequential recruitment of NADPH oxidase components into lipid rafts
C Guichard, E Pedruzzi, C Dewas, M Fay… - Journal of Biological …, 2005 - ASBMB
The superoxide-producing phagocyte NADPH oxidase consists of a membrane-bound
flavocytochrome b 558, the cytosol factors p47 phox, p67 phox, p40 phox, and the small
GTPase Rac2, which translocate to the membrane to assemble the active complex following
neutrophil activation. Interleukin-8 (IL-8) does not activate NADPH oxidase, but potentiates
the oxidative burst induced by stimuli such as formyl-methionyl-leucyl-phenylalanine (fMLP)
via a priming mechanism. The effect of IL-8 on the components of NADPH oxidase during …
flavocytochrome b 558, the cytosol factors p47 phox, p67 phox, p40 phox, and the small
GTPase Rac2, which translocate to the membrane to assemble the active complex following
neutrophil activation. Interleukin-8 (IL-8) does not activate NADPH oxidase, but potentiates
the oxidative burst induced by stimuli such as formyl-methionyl-leucyl-phenylalanine (fMLP)
via a priming mechanism. The effect of IL-8 on the components of NADPH oxidase during …