[HTML][HTML] α1-Antitrypsin, old dog, new tricks: α1-antitrypsin exerts in vitro anti-inflammatory activity in human monocytes by elevating cAMP
SM Janciauskiene, IM Nita, T Stevens - Journal of biological chemistry, 2007 - ASBMB
Regulation of serine protease activity is considered to be the sole mechanism for the
function of α 1-antitrypsin (AAT). However, recent reports of the anti-inflammatory effects of
AAT are hard to reconcile with this classical mechanism. We discovered that two key
activities of AAT in vitro, namely inhibition of endotoxin-stimulated tumor necrosis factor-α
and enhancement of interleukin-10 in human monocytes, are mediated by an elevation of
cAMP and activation of cAMP-dependent protein kinase A. As expected with this type of …
function of α 1-antitrypsin (AAT). However, recent reports of the anti-inflammatory effects of
AAT are hard to reconcile with this classical mechanism. We discovered that two key
activities of AAT in vitro, namely inhibition of endotoxin-stimulated tumor necrosis factor-α
and enhancement of interleukin-10 in human monocytes, are mediated by an elevation of
cAMP and activation of cAMP-dependent protein kinase A. As expected with this type of …