[HTML][HTML] Liver X receptor (LXR) regulation of the LXRα gene in human macrophages
KD Whitney, MA Watson, B Goodwin… - Journal of Biological …, 2001 - ASBMB
The nuclear oxysterol receptors LXRα (NR1H3) and LXRβ (NR1H2) coordinately regulate
the expression of genes involved in the transport and catabolism of cholesterol. In
macrophages, LXR stimulates the transcription of genes encoding transporters involved in
cholesterol efflux, which may limit the transformation of these cells into foam cells in
response to lipid loading. Here, we report that natural and synthetic LXR ligands induce the
expression of the LXRα gene in primary human macrophages and differentiated THP-1 …
the expression of genes involved in the transport and catabolism of cholesterol. In
macrophages, LXR stimulates the transcription of genes encoding transporters involved in
cholesterol efflux, which may limit the transformation of these cells into foam cells in
response to lipid loading. Here, we report that natural and synthetic LXR ligands induce the
expression of the LXRα gene in primary human macrophages and differentiated THP-1 …