[HTML][HTML] Redox sensitivity of the ryanodine receptor interaction with FK506-binding protein
S Zissimopoulos, N Docrat, FA Lai - Journal of biological chemistry, 2007 - ASBMB
The ryanodine receptor (RyR) calcium release channel functions as a redox sensor that is
sensitive to channel modulators. The FK506-binding protein (FKBP) is an important
regulator of channel activity, and disruption of the RyR2-FKBP12. 6 association has been
implicated in cardiac disease. In the present study, we investigated whether the RyR-FKBP
association is redox-regulated. Using co-immunoprecipitation assays of solubilized native
RyR2 from cardiac muscle sarcoplasmic reticulum (SR) with recombinant [35 S] FKBP12. 6 …
sensitive to channel modulators. The FK506-binding protein (FKBP) is an important
regulator of channel activity, and disruption of the RyR2-FKBP12. 6 association has been
implicated in cardiac disease. In the present study, we investigated whether the RyR-FKBP
association is redox-regulated. Using co-immunoprecipitation assays of solubilized native
RyR2 from cardiac muscle sarcoplasmic reticulum (SR) with recombinant [35 S] FKBP12. 6 …