[HTML][HTML] Acute β-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells
A hyperadrenergic state is a seminal aspect of chronic heart failure. Also," Takotsubo stress
cardiomyopathy," is associated with increased plasma catecholamine levels. The
mechanisms of myocyte damage secondary to excess catecholamine exposure as well as
the consequence of this neurohumoral burst on cardiac stem cells (CSCs) are unknown.
Cardiomyocytes and CSCs were exposed to high doses of isoproterenol (ISO), in vivo and in
vitro. Male Wistar rats received a single injection of ISO (5 mg kg-1) and were sacrificed 1, 3 …
cardiomyopathy," is associated with increased plasma catecholamine levels. The
mechanisms of myocyte damage secondary to excess catecholamine exposure as well as
the consequence of this neurohumoral burst on cardiac stem cells (CSCs) are unknown.
Cardiomyocytes and CSCs were exposed to high doses of isoproterenol (ISO), in vivo and in
vitro. Male Wistar rats received a single injection of ISO (5 mg kg-1) and were sacrificed 1, 3 …