The incidence of pre-eclampsia among couples consisting of Japanese women and Caucasian men

S Saito, Y Takeda, M Sakai, M Nakabayahi… - Journal of reproductive …, 2006 - Elsevier
Recent data from Hiby (2004) have suggested that a combination of maternal killer
immunoglobulin receptor (KIR) AA genotype and fetal HLA-C2 genotype increases the risk
of pre-eclampsia. Different human populations have a reciprocal relationship between KIR
AA frequency and HLA-C2 frequency. Japanese people have highest frequency of KIR-AA
alleles and lowest frequency of HLA-C2 alleles. However, Caucasians have a moderate
frequency of KIR-AA and HLA-C2 alleles. If this hypothesis is correct, the incidence of pre …