[HTML][HTML] Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation
K Fujimoto, PT Hanson, H Tran, EL Ford, Z Han… - Journal of Biological …, 2009 - ASBMB
There are three types of cell death; apoptosis, necrosis, and autophagy. The possibility that
activation of the macroautophagy (autophagy) pathway may increase beta cell death is
addressed in this study. Increased autophagy was present in pancreatic islets from Pdx1+/−
mice with reduced insulin secretion and beta cell mass. Pdx1 expression was reduced in
mouse insulinoma 6 (MIN6) cells by delivering small hairpin RNAs using a lentiviral vector.
The MIN6 cells died after 7 days of Pdx1 deficiency, and autophagy was evident prior to the …
activation of the macroautophagy (autophagy) pathway may increase beta cell death is
addressed in this study. Increased autophagy was present in pancreatic islets from Pdx1+/−
mice with reduced insulin secretion and beta cell mass. Pdx1 expression was reduced in
mouse insulinoma 6 (MIN6) cells by delivering small hairpin RNAs using a lentiviral vector.
The MIN6 cells died after 7 days of Pdx1 deficiency, and autophagy was evident prior to the …