Mitochondrial DNA mutations in focal segmental glomerulosclerosis lesions
K Yamagata, K Muro, J Usui, M Hagiwara… - Journal of the …, 2002 - journals.lww.com
Glomerular epithelial cells are primary pathogenic sites in focal segmental
glomerulosclerosis (FGS) lesions. Glomerular epithelial cells are regarded as terminally
differentiated cells that do not proliferate. These characteristics are also noted for neurons
and muscular cells, which are major sites of mitochondrial DNA (mtDNA) mutation
accumulation. Screening for mtDNA mutations was performed with renal biopsy specimens
from patients with primary FGS and patients with IgA nephropathy (as subjects with …
glomerulosclerosis (FGS) lesions. Glomerular epithelial cells are regarded as terminally
differentiated cells that do not proliferate. These characteristics are also noted for neurons
and muscular cells, which are major sites of mitochondrial DNA (mtDNA) mutation
accumulation. Screening for mtDNA mutations was performed with renal biopsy specimens
from patients with primary FGS and patients with IgA nephropathy (as subjects with …