Course of renal injury in the Mpv17-deficient transgenic mouse
T O'BRYAN, H Weiher, HG Rennke… - Journal of the …, 2000 - journals.lww.com
The mutant Mpv17 mouse is a transgenic strain that fails to express a protein that is normally
expressed in the kidney and that is associated with peroxisomes. The present studies
provide a quantitative examination of renal function and structure in this strain compared to
its control CFW strain. By 52 wk of age, the mutant strain developed proteinuria (urinary
protein to creatinine ratio: 25±14 versus 3±1, mutant versus control), albuminuria (urinary
albumin to creatinine ratio: 23±15 versus 0.1±0.1, mutant versus control), and …
expressed in the kidney and that is associated with peroxisomes. The present studies
provide a quantitative examination of renal function and structure in this strain compared to
its control CFW strain. By 52 wk of age, the mutant strain developed proteinuria (urinary
protein to creatinine ratio: 25±14 versus 3±1, mutant versus control), albuminuria (urinary
albumin to creatinine ratio: 23±15 versus 0.1±0.1, mutant versus control), and …