[HTML][HTML] Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing …

D Lu, J Shen, MD Vil, H Zhang, X Jimenez… - Journal of Biological …, 2003 - ASBMB
Vascular endothelial growth factor (VEGF) and its receptors have been implicated in
promoting solid tumor growth and metastasis via stimulating tumor-associated
angiogenesis. We previously identified several fully human neutralizing anti-VEGF receptor
2 (or kinase inserting domain-containing receptor (KDR)) antibodies from a large antibody
phage display library. These antibodies bind specifically to KDR, block VEGF/KDR
interaction, and inhibit VEGF-induced proliferation of human endothelial cells and migration …