Pathogenic mechanisms of B-lymphocyte dysfunction in HIV disease
S Moir, AS Fauci - Journal of Allergy and Clinical Immunology, 2008 - Elsevier
HIV disease is associated with abnormalities in all major lymphocyte populations, including
B cells. Aberrancies in the B-cell compartment can be divided into 3 broad categories:
changes that arise as a result of HIV-induced immune activation, changes that arise as a
result of HIV-induced lymphopenia, and changes that arise independently of these 2
parameters. We review recent developments in all 3 categories of abnormalities and
highlight how observations made in the early years of the HIV epidemic are better …
B cells. Aberrancies in the B-cell compartment can be divided into 3 broad categories:
changes that arise as a result of HIV-induced immune activation, changes that arise as a
result of HIV-induced lymphopenia, and changes that arise independently of these 2
parameters. We review recent developments in all 3 categories of abnormalities and
highlight how observations made in the early years of the HIV epidemic are better …