[HTML][HTML] MicroRNAs and cancer: short RNAs go a long way
MicroRNAs (miRNAs) may be important regulators of gene expression. By modulating
oncogenic and tumor suppressor pathways they could, in principle, contribute to
tumorigenesis. Consistent with this hypothesis, recurrent genetic and epigenetic alterations
of individual miRNAs are found in some tumors. Functional studies are now elucidating the
mechanism of action of putative oncogenic and tumor suppressor miRNAs.
oncogenic and tumor suppressor pathways they could, in principle, contribute to
tumorigenesis. Consistent with this hypothesis, recurrent genetic and epigenetic alterations
of individual miRNAs are found in some tumors. Functional studies are now elucidating the
mechanism of action of putative oncogenic and tumor suppressor miRNAs.
MicroRNAs (miRNAs) may be important regulators of gene expression. By modulating oncogenic and tumor suppressor pathways they could, in principle, contribute to tumorigenesis. Consistent with this hypothesis, recurrent genetic and epigenetic alterations of individual miRNAs are found in some tumors. Functional studies are now elucidating the mechanism of action of putative oncogenic and tumor suppressor miRNAs.
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