[HTML][HTML] Phosphorylation of tyrosine 568 controls nuclear export of Nrf2
AK Jain, AK Jaiswal - Journal of biological chemistry, 2006 - ASBMB
Nuclear factor Nrf 2, under normal conditions, is retained in the cytosol by INrf 2.
Antioxidants and oxidants antagonize this interaction, resulting in the release of Nrf 2. Nrf 2
translocates to the nucleus binds to ARE and activates a battery of chemopreventive genes.
Once this is achieved, Nrf 2 is exported out of the nucleus, binds with INrf 2, and degrades.
Nrf 2 contains well defined signals that control nuclear import and export of Nrf 2. The
present studies demonstrate that phosphorylation of tyrosine 568 is required for Crm1 …
Antioxidants and oxidants antagonize this interaction, resulting in the release of Nrf 2. Nrf 2
translocates to the nucleus binds to ARE and activates a battery of chemopreventive genes.
Once this is achieved, Nrf 2 is exported out of the nucleus, binds with INrf 2, and degrades.
Nrf 2 contains well defined signals that control nuclear import and export of Nrf 2. The
present studies demonstrate that phosphorylation of tyrosine 568 is required for Crm1 …