A fingerprint left by cytomegalovirus infection in the human T cell compartment
PJEJ van de Berg, A van Stijn, IJM Ten Berge… - Journal of clinical …, 2008 - Elsevier
Latent infection with human cytomegalovirus (HCMV) is accompanied by a strong increase
in the number of resting, effector-type CD4+ and CD8+ T cells with constitutive cytolytic
activity in the circulation. Longitudinal studies in kidney transplant recipients revealed that
effector cells emerge early after the initial viral burst and acquire their stable phenotype in
the months following primary infection. Although it is yet unsettled whether these cells are all
specific for CMV encoded or induced antigens, it has become clear that T cell responses to …
in the number of resting, effector-type CD4+ and CD8+ T cells with constitutive cytolytic
activity in the circulation. Longitudinal studies in kidney transplant recipients revealed that
effector cells emerge early after the initial viral burst and acquire their stable phenotype in
the months following primary infection. Although it is yet unsettled whether these cells are all
specific for CMV encoded or induced antigens, it has become clear that T cell responses to …