[HTML][HTML] Constitutive signaling of the human cytomegalovirus-encoded chemokine receptor US28
P Casarosa, RA Bakker, D Verzijl, M Navis… - Journal of Biological …, 2001 - ASBMB
Previously it was shown that the HHV-8-encoded chemokine receptor ORF74 shows
considerable agonist-independent, constitutive activity giving rise to oncogenic
transformation (Arvanitakis, L., Geras-Raaka, E., Varma, A., Gershengorn, MC, and
Cesarman, E.(1997) Nature 385, 347–350). In this study we report that a second viral-
encoded chemokine receptor, the human cytomegalovirus-encoded US28, also efficiently
signals in an agonist-independent manner. Transient expression of US28 in COS-7 cells …
considerable agonist-independent, constitutive activity giving rise to oncogenic
transformation (Arvanitakis, L., Geras-Raaka, E., Varma, A., Gershengorn, MC, and
Cesarman, E.(1997) Nature 385, 347–350). In this study we report that a second viral-
encoded chemokine receptor, the human cytomegalovirus-encoded US28, also efficiently
signals in an agonist-independent manner. Transient expression of US28 in COS-7 cells …