[HTML][HTML] Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action

K Fulzele, DJ DiGirolamo, Z Liu, J Xu… - Journal of Biological …, 2007 - ASBMB
Defective bone formation is common in patients with diabetes, suggesting that insulin
normally exerts anabolic actions in bone. However, because insulin can cross-activate the
insulin-like growth factor type 1 receptor (IGF-1R), which also functions in bone, it has been
difficult to establish the direct (IGF-1-independent) actions of insulin in osteoblasts. To
overcome this problem, we examined insulin signaling and action in primary osteoblasts
engineered for conditional disruption of the IGF-1 receptor (ΔIGF-1R). Calvarial osteoblasts …